The Effect of Type, Duration and Intensity of Exercise on Inflammatory Markers CRP, IL-6 and IL-18 in Metabolic Syndrome Patients: A Systematic Review

Metabolic syndrome (MetS) has become a major clinical challenge worldwide due to rise of urbanisation, surplus energy intake, increasing obesity and sedentary lifestyle. C-reactive protein (CRP), interleukin-6 (IL-6) interleukin-18 (IL-18) are associated with MetS. We performed systematic review investigate the effects exercise on these markers in MetS patients therefore determine best regime for them. searched Medline (Pubmed Ovid), Scopus CINAHL databases. The searches were standardized by using same search strategy which included terms such as ‘metabolic syndrome’, ‘CRP’, ‘IL-6’, ‘IL-18’ ‘exercise’. Only human studies published from Jan 2007 May 2018 included. A total 11 trials (466 participants) selected. Majority randomized controlled (90.9%). All showed decrease serum levels biomarkers. However, not all statistically significant. main type most was aerobic. Aerobic-resistance more effective rather than aerobic alone, but only sole intervention. Aerobic promising role lifestyle intervention It is concluded that should have combined aerobic-resistance exercise.